On Brian Setzer’s Health Concerns, Inability to Play Guitar

It’s never easy getting old. It can be even harder to witness your favorite performers get old, and lose touch with some of the gifts that made them legends in their time.
We had another one of those moments recently. With no warning, and with little follow up information, rockabilly legend, big band leader, and bona fide guitar god Brian Setzer let it be known that he is no longer able to play the instrument that made him famous, at least for now. Citing an unnamed auto-immune disease, he made the announcement on February 13th, seeming to give an explanation why his show calendar for 2025 currently sits empty.
“Hi everybody, I just wanted to check in with you all,” Setzer said. “Towards the end of the last Stray Cats tour I noticed that my hands were cramping up. I’ve since discovered that I have an auto-immune disease. I cannot play guitar. There is no pain, but it feels like I am wearing a pair of gloves when I try to play.”
Setzer went on to say, “I have seen some progress in that I can hold a pen and tie my shoes. I know this sounds ridiculous, but I was at a point where I couldn’t even do that. Luckily, I have the best hospital in the world down the block from me. It’s called the Mayo Clinic. I know I will beat this, it will just take some time. I love you all, Brian.”
Brian Setzer wasn’t just vital to the major revitalization of one important form of classic American music. He was responsible for two of them. Setzer became an American original by championing the sounds and styles that the rest of popular music was so quick to toss aside. He knew all the way back in the ’80s that the early sounds of American post-war music would be eternally in style like a good pair of blue jeans.
When Brian Setzer formed The Stray Cats in 1979 with Lee Rocker and Slim Jim Phantom, they took the outmoded sounds of the Sun Records era and made them the very definition of cool once again. They weren’t a version of punk. They were straight rockabilly in a way that made the punk rockers envious, and were able to get hits on the radio and influence modern music.
Then in the late ’90s with his 17-piece Brian Setzer Orchestra, he was seminal to the era’s swing revolution. The band’s 1998 album The Dirty Boogie went Double Platinum, and won multiple Grammy Awards. There’s perhaps nobody who has done more to keep the classic sounds of American music alive than Brian Setzer.
His work also regularly veered into the country realm as you can imagine. Stray Cat tracks such as “Lookin’ Better Every Beer” or “18 Miles From Memphis” show off Brian Setzer’s country side for sure. In 2023 when he released his latest record The Devil Always Collects, Setzer included a cover of the classic Del Reeves country song “Girl On The Billboard.”
But Brian Setzer doesn’t belong to country. He belongs to all of American music, fearlessly refusing to believe anything is irrelevant and out-of-style, and then setting off to prove it. Setzer is the living embodiment of how good music never grows old, and will always withstand the test of time.
The news about Setzer feels especially painful from what you know he’s contributed as a guitar player, and what you hope he can contribute in the future. Irrespective of the style or genre he decided to work with in a given era, Setzer was revered worldwide as a player. He even once performed as a side player for Robert Plant in the Honeydrippers. Brian Setzer seems to be perennially 24, with a unwavering and endless enthusiasm for the music, even as he entered his 60s. (He’s 65 now).
Hopefully, whatever is affecting Brian Setzer’s hands and body has a solution. It sounds from his statement that there is promise, and he’ll hopefully be playing his signature hollow body Gretsch guitar once again. But either way, what a man, what a life, and what we owe to Brian Setzer for refusing to give up or toss aside the timeless music that has made the American experience so enjoyable.
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February 22, 2025 @ 9:05 am
one of less than five guitarists who are inexplicably able to play any style of music like a native player. Alongside Glen Campbell and Danny Gatton, one of the most versatile, flexible guitarists in the history of the business.
Don’t worry about tying your shoes, Brian. you’ll be in good company if you can’t. I’ve heard Einstein couldn’t do it and neither could Stephen Hawking
February 22, 2025 @ 10:41 am
That’s why I wear Tony Lamas.
February 22, 2025 @ 9:25 am
What a beautiful article. Thank you for writing this.
So grateful to have seen him in concert last year.
February 22, 2025 @ 10:39 pm
agreed, thank you di
February 22, 2025 @ 9:31 am
It is utterly inexplicable to me that Brian Setzer isn’t in the Rock and Roll Hall of Fame, even given that it seems to have morphed into a Popular Music Hall of Fame–a place he would belong as well.
My prayers go out to you Brian! You’re a true American treasure.
February 22, 2025 @ 8:35 pm
Well, it’s utterly inexplicable to me that Jim Croce is not in the Rock and Roll Hall of Fame, but then, they don’t come to me for guidance or advice on who should be in the H-o-F.
February 23, 2025 @ 5:38 am
Hear hear!
Phil Collins, the solo artist, is also not in the R&R Hall somehow. Neither is Kansas or the Marshall Tucker Band. How long did it take the Cars to get in?
February 26, 2025 @ 10:32 am
I won’t give the Hall o’ Fame an ounce of respect until they induct Los Lobos.
February 22, 2025 @ 11:04 am
This piece does real justice to Brian Setzer.
March 2, 2025 @ 7:54 pm
Brian Setzer will be back.I have a autoimmune disease that did the same to myself.There is many treatments .The hard part is finding the one that works for you.Medications take 2 to 4 months to help.GOD BLESS.
February 22, 2025 @ 11:26 am
Sometimes you just have to shake your head.
Brian, you’re loved and respected. Here’s another rando on the internet hoping you’ll get it back, but if you don’t, you’ve left a major legacy and inspiration for guitar players everywhere.
Not bad for a greaser.
February 22, 2025 @ 11:52 am
I remember the first time I saw Setzer with the Stray Cats on the old ABC Fridays show. I was watching that show with a girlfriend (that I later married) and when the show announced the Stray Cats, I saw a skinny guy with waterfall hair and a guitar, an acoustic bass, and the drummer with a very minimal drum kit (and the drummer was playing standing up). Just before the music started, I said to my sweetie, “I’ll bet these guys will really suck!” But then when the music started, it didn’t take long before my girlfriend and I were on our feet and dancing around the living room. The Stray Cats were like a breath of fresh air compared to all of the lame late-1970s acts that were on the radio.
Get well, Brian! We hope to get many more recordings and performances from you!
February 22, 2025 @ 12:34 pm
There are many Brian Setzer videos on YouTube. This one does a nice job of summarizing his career. https://youtu.be/9F9D089VwGo?feature=shared
February 22, 2025 @ 3:36 pm
Hes the modern day Rockabilly King. No one made Gretsch guitars more cool than him. One side point that I’ve admired about him is that he’s changed it up many times over the years with bands and styles.
What a musically sophisticated cat he is. He reads, arranges, writes and scores music, sings like a crooner, belts like a rocker, shreds like a rock star, picks banjo like a grasser, and jazzes like a Chicago master. Hes all that in one pompadoured package!
Bummer on this auto- immune condition. Here’s hoping he figures it out.
February 22, 2025 @ 7:53 pm
I love his vocals on “I Won’t Stand In Your Way” (Cats 1982).
February 22, 2025 @ 8:18 pm
The news hit me physically. i really found great joy in his big band sound. knew people who lived around him on Long Island who said he was always walking up to people working on their cars, offering to help, or hearing someone jamming in their garage and coming over to join in. everything i heard about him was positive and how much he loved music
i forget which album it is from but it gives me some laughs to shout out “bonsoir, Montreal!!” at random moments.
while this is horrible news, i hope he considers remaining a singer, and touring when he feels better. it must kill inside not to be able to play guitar, but i think he still has a lot to give the world of music
February 23, 2025 @ 7:19 am
With the Orchestra: One Rockin’ Night – Live in Montreal 1995
February 23, 2025 @ 11:03 pm
thank you
i do not have CDs handy anymore.
February 23, 2025 @ 7:10 am
I won’t lie and say I was ever a huge Stray Cats fan, but will admit that I always found myself singing along and tapping my toes whenever a Stray Cats songs came on. I remember as a teen when the song Stray Cat Strut began playing on my local hard rock station. I think they initially just played it for fun. Who knew the song would blow up? Who knew a few decades later that Setzer and the Stray Cats would still be culturally relevant?
Huge fan or not, I have always liked and respected Setzer and the Stray Cats. Hope he finds health and healing.
February 23, 2025 @ 10:59 am
“Stray Cat Strut” is probably one of the first examples where radio followed MTV. I remember the video for it {and “Rock This Town”} being played on MTV for months before radio caught up. This really sucks. Brian is a guitar hero of mine, too. My favorite TV appearance of him is the TNN show with him, Marty Stuart, and Ricky Skaggs. Twang to the max!
February 23, 2025 @ 8:15 am
Love Brian and pray for his recovery, his Christmas albums with the orchestra are mainstays at my house during Christmas and no one his cooler album cover art as well!
Thanks for the write up Trig!
February 23, 2025 @ 11:44 am
A unnamed autoimmune disease? Sounds like the poor chap is suffering from a covid vaccine injury, aka VAIDS. Get well asap. Dudes cool af.
February 24, 2025 @ 11:54 am
Stop with the bullshit.VAIDS (Vaccine Acquired Immunodeficiency Syndrome) is not an actual medical condition but was instead invented by the right-wing, pseudo scientific medical group America’s Frontline Doctors led by SImone Gold. Feel free to research her history…
February 24, 2025 @ 12:55 pm
Enjoy the myocarditis, chief.
February 24, 2025 @ 12:57 pm
Folks, please no more comments on this thread. Let’s all appreciate this is a country music website that people come to get away from these very kinds of topics.
Thanks!
February 24, 2025 @ 3:37 pm
He performed the kickass theme song to the House of Mouse.
Legend.
February 26, 2025 @ 5:23 am
That was a great write up Trig! …and it’s great to see so much support for Brian Setzer and his music on this site. I liked his stray cat stuff at the time he hit it big but didn’t follow him closely. Over the past couple of years, though, something caused me to go back and start listening to all of his music.What a talented guy. Amazing guitarist, great singer, tremendous songwriter, and able to play in so many different styles. Seeing above that he is also a down to earth and giving person makes me love him all that much more. Hopefully all these positive vibes wishing him a big recovery will help move things in the right direction.
February 26, 2025 @ 7:03 pm
Brian Setzer’s solo debut, Knife Feels Like Justice, is Mt Rushmore stuff, along with Steve Earle, Blue Rodeo, Mellencamp and Jayhawks ushering in Americana and later Red Dirt. Brian pls heal and promise no more jabs!
March 2, 2025 @ 8:52 pm
Hello to Brian. I had the good fortune to meet you in person outside of your working environment.
As a real person. First time was in Encinitas California. You are a real good person, Loved watching you at the Belly up.
You are not lost you are always with us. You are a little down maybe, you are not out.
Thank you for sharing your self with us all.
March 3, 2025 @ 4:52 am
My wife and I received swing dance lessons for a wedding gift in 1999. I thought “what an odd gift” but my wife twisted my arm till I went. What a great time we’ve had over the last 25 years from this very thoughtful gift. Turns out her aunt who gave this gift to us knew I liked the Stray Cats. Thank you Mr. Setzer for a lifetime of great music
March 5, 2025 @ 1:54 pm
never was a fan of his guitar anyway. hes like a crappy version of Danny Gatton